| name | Hub | image | date Ceased operations | date Commenced operations | IATA Code | ICAO Code | city Headquarters | administrative division Headquarters | country Headquarters | continent Headquarters | Country | continent | Parent | number of aircrafts | number of destinations | Website |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ACES Colombia | José María Córdova International Airport |  | 2003 | 1972 | VX | AES | Medellín | Antioquia Department | Colombia | Americas | Colombia | Americas | AVIANCA | 43 | Website | |
| Aerolínea de Antioquia | Olaya Herrera Airport |  | 29/03/2019 | 1987 | ANQ | Medellín | Antioquia Department | Colombia | Americas | Colombia | Americas | 13 | 21 | Website | ||
| Avianca Cargo | El Dorado International Airport |  | 1973 | QT | TPA | Medellín | Antioquia Department | Colombia | Americas | Colombia | Americas | 4 | 20 | Website | ||
| Heliandes | 2004 | 1998 | Medellín | Antioquia Department | Colombia | Americas | Colombia | Americas | Website | |||||||
| SARPA | 1980 | Medellín | Antioquia Department | Colombia | Americas | Colombia | Americas | 2 | Website |