| name | Hub | image | date Ceased operations | date Commenced operations | IATA Code | ICAO Code | city Headquarters | administrative division Headquarters | country Headquarters | continent Headquarters | Country | continent | Parent | number of aircrafts | number of destinations | Website |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AmericanConnection | O'Hare International Airport |  | 19/08/2014 | 02/12/2001 | Indianapolis | Indiana | United States | Americas | United States | Americas | American Airlines Group | 5 | Website | |||
| ATA Airlines | Midway International Airport |  | 03/04/2008 | 1973 | TZ | AMT | Indianapolis | Indiana | United States | Americas | United States | Americas | Southwest airlines | 29 | 13 | Website |
| Chautauqua Airlines | | 31/12/2014 | 1973 | RP | CHQ | Indianapolis | Indiana | United States | Americas | United States | Americas | Republic Airways Holdings | 41 | 52 | Website | |
| Lake Central Airlines | 1968 | 1950 | Indianapolis | Indiana | United States | Americas | United States | Americas | 3 | Website | ||||||
| Shuttle America | O'Hare International Airport |  | 30/01/2017 | 1995 | S5 | TCF | Indianapolis | Indiana | United States | Americas | United States | Americas | Republic Airways Holdings | 113 | Website |