| name | Hub | image | date Ceased operations | date Commenced operations | IATA Code | ICAO Code | city Headquarters | administrative division Headquarters | country Headquarters | continent Headquarters | Country | continent | Parent | number of aircrafts | number of destinations | Website |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Air New England (1970–1981) | LaGuardia Airport | 1981 | 1970 | Boston | Massachusetts | United States | Americas | United States | Americas | Website | ||||||
| Cape Air | Barnstable Municipal Airport |  | 1989 | 9K | KAP | Barnstable, Massachusetts | Massachusetts | United States | Americas | United States | Americas | 93 | 36 | Website | ||
| Colonial Air Transport | 1930 | 1926 | Boston | Massachusetts | United States | Americas | Website | |||||||||
| Island Airlines | Barnstable Municipal Airport | 11/12/2015 | 1991 | IS | ISA | Barnstable, Massachusetts | Massachusetts | United States | Americas | United States | Americas | 12 | 2 | Website | ||
| New England & Western Air Transportation Co. | 1930 | 1930 | Springfield, Massachusetts | Massachusetts | United States | Americas | United States | Americas | Website |