| name | Hub | image | date Ceased operations | date Commenced operations | IATA Code | ICAO Code | city Headquarters | administrative division Headquarters | country Headquarters | continent Headquarters | Country | continent | Parent | number of aircrafts | number of destinations | Website |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CCAir | 04/11/2002 | 1987 | Charlotte, North Carolina | North Carolina | United States | Americas | Mesa Air Group | Website | ||||||||
| Leisure Air | 02/1995 | 1992 | L8 | LWD | Winston-Salem, North Carolina | North Carolina | United States | Americas | United States | Americas | 15 | Website | ||||
| Mid-Atlantic Freight | 1990 | MDC | Greensboro, North Carolina | North Carolina | United States | Americas | United States | Americas | 8 | Website | ||||||
| Midway Airlines (1993–2003) | Raleigh–Durham International Airport | 30/10/2003 | 15/11/1993 | JI | MDW | Morrisville, North Carolina | North Carolina | United States | Americas | United States | Americas | 33 | 33 | Website | ||
| Piedmont Airlines (1948–1989) | Charlotte Douglas International Airport |  | 1989 | 1948 | PI | PDT | Winston-Salem, North Carolina | North Carolina | United States | Americas | United States | Americas | Us airways | 12 | 95 | Website |