| name | Hub | image | date Ceased operations | date Commenced operations | IATA Code | ICAO Code | city Headquarters | administrative division Headquarters | country Headquarters | continent Headquarters | Country | continent | Parent | number of aircrafts | number of destinations | Website |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Aerolíneas Sudamericanas | 2008 | Santa Cruz de la Sierra | Santa Cruz Department | Bolivia | Americas | Bolivia | Americas | 1 | 5 | Website | ||||||
| AeroSur | Viru Viru International Airport |  | 2012 | 1992 | 5L | RSU | Santa Cruz de la Sierra | Santa Cruz Department | Bolivia | Americas | Bolivia | Americas | 11 | 20 | Website | |
| Lamia |  | 01/12/2016 | 01/2016 | Santa Cruz de la Sierra | Santa Cruz Department | Bolivia | Americas | Bolivia | Americas | 2 | Website |