| name | Hub | image | date Ceased operations | date Commenced operations | IATA Code | ICAO Code | city Headquarters | administrative division Headquarters | country Headquarters | continent Headquarters | Country | continent | Parent | number of aircrafts | number of destinations | Website |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FedEx Express | Memphis International Airport |  | 17/04/1973 | FX | FDX | Memphis, Tennessee | Tennessee | United States | Americas | United States | Americas | 659 | 375 | Website | ||
| Mesaba Airlines | Detroit Metropolitan Airport |  | After 04/01/2012 | 04/02/1974 | XJ | MES | Memphis, Tennessee | Tennessee | United States | Americas | United States | Americas | Pinnacle Airlines Corp. | 86 | 64 | Website |
| Southern Airways Express | Memphis International Airport | 2013 | 9X | LTD | Memphis, Tennessee | Tennessee | United States | Americas | United States | Americas | 23 | 10 | Website | |||
| Chicago and Southern Air Lines | 1953 | 1934 | CS | CSA | Memphis, Tennessee | Tennessee | United States | Americas | United States | Americas | Website | |||||
| Endeavor Air | Minneapolis–Saint Paul International Airport |  | 1985 | 9E | FLG | Memphis, Tennessee | Tennessee | United States | Americas | United States | Americas | Delta air lines | 136 | Website |