| name | Hub | image | date Ceased operations | date Commenced operations | IATA Code | ICAO Code | city Headquarters | administrative division Headquarters | country Headquarters | continent Headquarters | Country | continent | Parent | number of aircrafts | number of destinations | Website |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Aeroperlas | Albrook "Marcos A. Gelabert" International Airport |  | 29/02/2012 | 1970 | WL | APP | Panama City | Panamá | Panama | Americas | Panama | Americas | AMR Corporation | 4 | 12 | Website |
| Air Panamá Internacional | Tocumen International Airport |  | 1990 | 1968 | OP | API | Panama City | Panamá | Panama | Americas | Panama | Americas | Iberia | Website | ||
| Air Services Cargo | 2003 | 2002 | Panama City | Panamá | Panama | Americas | Panama | Americas | Website | |||||||
| Copa Airlines | Tocumen International Airport |  | 15/08/1947 | CM | CMP | Panama City | Panamá | Panama | Americas | Panama | Americas | Copa holdings | 69 | Website | ||
| DHL Aero Expreso | Tocumen International Airport |  | 1996 | D5 | DAE | Panama City | Panamá | Panama | Americas | Panama | Americas | 3 | Website |