| name | Hub | image | date Ceased operations | date Commenced operations | IATA Code | ICAO Code | city Headquarters | administrative division Headquarters | country Headquarters | continent Headquarters | Country | continent | Parent | number of aircrafts | number of destinations | Website |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pan American World Airways | Frankfurt Airport |  | 04/12/1991 | 19/10/1927 | PA | PAA | Miami | Florida | United States | Americas | United States | Americas | Pan American World Airways | 152 | 224 | Website |
| SunExpress Deutschland | Frankfurt Airport |  | 2011 | XG | SXD | Frankfurt | Hesse | Germany | Europe | Germany | Europe | Sunexpress | 17 | 20 | Website | |
| Lufthansa Regional | Frankfurt Airport |  | 2004 | Munich | Bavaria | Germany | Europe | Germany | Europe | Lufthansa | 57 | 80 | Website | |||
| Condor (airline) | Frankfurt Airport |  | 1956 | DE | CFG | Frankfurt | Hesse | Germany | Europe | Germany | Europe | Thomas Cook | 42 | 77 | Website | |
| Aero Lloyd | Frankfurt Airport |  | 16/10/2003 | 03/1981 | YP | AEF | Oberursel (Taunus) | Hesse | Germany | Europe | Germany | Europe | BayernLB | 57 | 59 | Website |