| name | Hub | image | date Ceased operations | date Commenced operations | IATA Code | ICAO Code | city Headquarters | administrative division Headquarters | country Headquarters | continent Headquarters | Country | continent | Parent | number of aircrafts | number of destinations | Website |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pakistan International Airlines | Jinnah International Airport |  | 1946 | PK | PIA | Karachi | Sindh | Pakistan | Asia | Pakistan | Asia | 2(x)ist | 38 | 82 | Website | |
| Pearl Air | Jinnah International Airport | 2004 | PRL | Karachi | Sindh | Pakistan | Asia | Pakistan | Asia | 6 | Website | |||||
| Bhoja Air | Jinnah International Airport | 04/2000 | 1993 | B4 | BHO | Karachi | Sindh | Pakistan | Asia | Pakistan | Asia | 3 | 5 | Website | ||
| Air Indus | Jinnah International Airport |  | 01/07/2015 | 28/07/2013 | I6 | MPK | Karachi | Sindh | Pakistan | Asia | Pakistan | Asia | 1 | 8 | Website | |
| Aero Asia International | Jinnah International Airport |  | 19/03/2007 | 04/05/1993 | E4 | RSO | Karachi | Sindh | Pakistan | Asia | Pakistan | Asia | 11 | Website |