| name | Hub | image | date Ceased operations | date Commenced operations | IATA Code | ICAO Code | city Headquarters | administrative division Headquarters | country Headquarters | continent Headquarters | Country | continent | Parent | number of aircrafts | number of destinations | Website |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LATAM Ecuador | Mariscal Sucre International Airport |  | 2002 | XL | LNE | Guayaquil | Guayas | Ecuador | Americas | Ecuador | Americas | LATAM Airlines Group | 5 | Website | ||
| Avianca Ecuador | Mariscal Sucre International Airport |  | 1986 | 2K | GLG | Quito | Pichincha | Ecuador | Americas | Ecuador | Americas | AVIANCA | 10 | 10 | Website | |
| Ecuatoriana de Aviación | Mariscal Sucre International Airport |  | 2006 | 08/1957 | EU | EEA | Quito | Pichincha | Ecuador | Americas | Ecuador | Americas | VASP | 30 | Website | |
| DHL Ecuador | Mariscal Sucre International Airport |  | 1991 | 7T | RTM | Guayaquil | Guayas | Ecuador | Americas | Ecuador | Americas | DHL Aero Expreso | 1 | 2 | Website | |
| TAME | Mariscal Sucre International Airport |  | 1962 | EQ | TAE | Quito | Pichincha | Ecuador | Americas | Ecuador | Americas | 25 | Website |