| name | Hub | image | date Ceased operations | date Commenced operations | IATA Code | ICAO Code | city Headquarters | administrative division Headquarters | country Headquarters | continent Headquarters | Country | continent | Parent | number of aircrafts | number of destinations | Website |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Shuttle America | O'Hare International Airport |  | 30/01/2017 | 1995 | S5 | TCF | Indianapolis | Indiana | United States | Americas | United States | Americas | Republic Airways Holdings | 113 | Website | |
| AmericanConnection | O'Hare International Airport |  | 19/08/2014 | 02/12/2001 | Indianapolis | Indiana | United States | Americas | United States | Americas | American Airlines Group | 5 | Website | |||
| Air Wisconsin | O'Hare International Airport |  | 23/08/1965 | ZW | AWI | Appleton, Wisconsin | Wisconsin | United States | Americas | United States | Americas | Gordmans | 70 | Website | ||
| North Central Airlines | O'Hare International Airport | 01/07/1979 | 1944 | NC | Minneapolis | Minnesota | United States | Americas | United States | Americas | 50 | 92 | Website | |||
| SkyWest Airlines | O'Hare International Airport |  | 1972 | OO | SKW | St. George, Utah | Utah | United States | Americas | United States | Americas | 291 | 186 | Website |