| name | Hub | image | date Ceased operations | date Commenced operations | IATA Code | ICAO Code | city Headquarters | administrative division Headquarters | country Headquarters | continent Headquarters | Country | continent | Parent | number of aircrafts | number of destinations | Website |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LATAM Paraguay | Silvio Pettirossi International Airport |  | 01/09/1996 | PZ | LAP | Asunción | Asunción | Paraguay | Americas | Paraguay | Americas | LATAM Airlines Group | 5 | 6 | Website | |
| Paranair | Silvio Pettirossi International Airport |  | 02/09/2015 | ZP | AZP | Asunción | Asunción | Paraguay | Americas | Paraguay | Americas | 2 | 6 | Website | ||
| Aerolíneas Paraguayas | Silvio Pettirossi International Airport | 2002 | 1994 | A8 | PAY | Luque | Central Department | Paraguay | Americas | Paraguay | Americas | LATAM Brasil | Website | |||
| Regional Paraguaya | Silvio Pettirossi International Airport |  | 2009 | 2008 | P7 | REP | Asunción | Asunción | Paraguay | Americas | Paraguay | Americas | 2 | 4 | Website |