| name | Hub | image | date Ceased operations | date Commenced operations | IATA Code | ICAO Code | city Headquarters | administrative division Headquarters | country Headquarters | continent Headquarters | Country | continent | Parent | number of aircrafts | number of destinations | Website |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Africa's Connection STP | 2014 | São Tomé | São Tomé | São Tomé and Príncipe | Africa | São Tomé and Príncipe | Africa | 3 | 6 | Website | ||||||
| Air São Tomé and Príncipe | São Tomé International Airport | 23/05/2006 | 1993 | KY | EQL | São Tomé | São Tomé | São Tomé and Príncipe | Africa | São Tomé and Príncipe | Africa | 1 | 3 | Website | ||
| STP Airways | São Tomé International Airport |  | 18/08/2008 | 8F | STP | São Tomé | São Tomé | São Tomé and Príncipe | Africa | São Tomé and Príncipe | Africa | EuroAtlantic Airways | 2 | 3 | Website |