| name | Number of deaths | date start | date end |
|---|---|---|---|
| 1346–1350 Plague (disease) Europe Asia Africa | 200,000,000 | 1346 | 1350 |
| 1545–1548 Viral hemorrhagic fever Mexico | 15,000,000 | 1545 | 1548 |
| 1576 Viral hemorrhagic fever Mexico | 2,500,000 | 1576 | 1576 |
| 1629–1631 Plague (disease) Italy | 280,000 | 1629 | 1631 |
| 541–542 Plague (disease) Europe | 50,000,000 | 0541 | 0542 |