| name | Hub | image | date Ceased operations | date Commenced operations | IATA Code | ICAO Code | city Headquarters | administrative division Headquarters | country Headquarters | continent Headquarters | Country | continent | Parent | number of aircrafts | number of destinations | Website |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| One Airlines | Arturo Merino Benítez International Airport |  | 2013 | ONS | Santiago | Santiago Metropolitan Region | Chile | Americas | Chile | Americas | 1 | 4 | Website | |||
| LATAM Chile | Arturo Merino Benítez International Airport |  | 1929 | LA | LAN | Las Condes | Santiago Metropolitan Region | Chile | Americas | Chile | Americas | LATAM Airlines Group | 189 | 67 | Website | |
| LATAM Express | Arturo Merino Benítez International Airport |  | 1998 | LU | LXP | Santiago | Santiago Metropolitan Region | Chile | Americas | Chile | Americas | LATAM Airlines Group | 12 | 19 | Website | |
| Latin American Wings | Arturo Merino Benítez International Airport |  | 2016 | JMR | Santiago | Santiago Metropolitan Region | Chile | Americas | Chile | Americas | 5 | 5 | Website | |||
| Air Comet Chile | Arturo Merino Benítez International Airport |  | 31/10/2008 | 2004 | 3I | DLU | Santiago | Santiago Metropolitan Region | Chile | Americas | Chile | Americas | 7 | 4 | Website |