| name | Hub | image | date Ceased operations | date Commenced operations | IATA Code | ICAO Code | city Headquarters | administrative division Headquarters | country Headquarters | continent Headquarters | Country | continent | Parent | number of aircrafts | number of destinations | Website |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1time Airline | O. R. Tambo International Airport |  | 02/11/2012 | 25/02/2004 | 1T | RNX | Johannesburg | Gauteng | South Africa | Africa | South Africa | Africa | 1time Airline | 11 | 9 | Website |
| Kulula.com | O. R. Tambo International Airport |  | 2001 | MN | CAW | Bonaero Park | Gauteng | South Africa | Africa | South Africa | Africa | Comair | 10 | 6 | Website | |
| Interair South Africa | O. R. Tambo International Airport |  | 1993 | D6 | ILN | Johannesburg | Gauteng | South Africa | Africa | South Africa | Africa | 4 | 8 | Website | ||
| Imperial Air Cargo | O. R. Tambo International Airport | 2006 | Johannesburg | Gauteng | South Africa | Africa | South Africa | Africa | Comair | 3 | 6 | Website | ||||
| South African Airways | O. R. Tambo International Airport |  | 01/02/1934 | SA | SAA | Johannesburg | Gauteng | South Africa | Africa | South Africa | Africa | 54 | 42 | Website |